Endocrine Abstracts

Background: Thyroid hormones have been shown to be necessary for proper function of brown adipose tissue (BAT) and cold induced thermogenesis (CIT) in rodent models. In humans hyperthyroidism has been demonstrated to activate BAT and increase thermogenesis. However, the data on CIT in humans in the hypothyroid vs. the euthyroid state are limited and conflicting.Methods: This was a prospective observational study. We recruited 40 patients presenting to a ...

Introduction: Patients with arginine vasopressin deficiency (AVP-D), known as central diabetes insipidus (cDI), often report psychological symptoms such as heightened anxiety levels, difficulties describing emotions, and depressed mood despite adequate treatment with desmopressin. Given the anatomical proximity, disruptions of the hypothalamic-pituitary axis causing an AVP-D could also disturb the oxytocin (OXT) system. OXT regulates socio-emotional functioning, including fear...

Background: The main challenge in the diagnosis of arginine vasopressin deficiency (AVP-deficiency, formerly known as central diabetes insipidus), is its distinction against primary polydipsia. Hypertonic saline stimulated copeptin showed a high diagnostic accuracy of 97% in distinguishing between AVP-deficiency and primary polydipsia (Fenske W, Refardt J, NEJM 2018), but comprises discomfort for patients and requires close sodium monitoring. Arginine stimulated copeptin showe...